Images of Science 2022

Our institute's research in pictures - find the highlights from the Social Media Advent Calendar 2022 here
January 17, 2023

Cell-Shape Manipulation via Cross-Shaped Micropattern

Confocal image of MF talin 1 and 2 ko cells, rescue transfected with Talin-GFP (cyan). Cells were seeded on cross-shaped micro pattern, coated with fibronectin. Actin was stained with SiR-Actin (magenta). From: Tim Pflästerer and Andreas Fink
January 17, 2023

Z-Stack of GUVs of Different Sizes

GUVs are used as eukaryotic cell-sized compartments for engineering synthetic cells. From: Maja Illig
January 17, 2023

DNA Filaments Inside Water-in-Oil Droplets

DNA filaments inside water-in-oil droplets laid to the periphery below 100 microns large. From: Maja Illig
January 17, 2023

DNA Hydrogel Baubles

They are a selection of different DNA hydrogel baubles. The two colours show two different types of DNA hydrogels. They both have the same structure and physical properties, but their DNA sequence is different to one another, so there is no mixing between the two gels thus causing them to be entangled, yet separate. From: Tobias Walther
January 17, 2023

DNA Hydrogel Baubles

They are a selection of different DNA hydrogel baubles. The two colours show two different types of DNA hydrogels. They both have the same structure and physical properties, but their DNA sequence is different to one another, so there is no mixing between the two gels thus causing them to be entangled, yet separate. From: Tobias Walther
January 17, 2023

Diamond Nano-Forest

Displayed is a scanning electron microscope (SEM) image of a pillar-like nanostructure etched into a diamond surface via reactive ion etching (RIE). Such nanostructures allow the reduction of the reflectivity of a surface and are widely referred to as moth-eye nanostructures. From: Louise Kaeswurm
January 17, 2023

Out of Alignment

640 nm/560 nm/488 nm/405 nm laser sources for a multi-beam fluorescent microscope. From: Julian Rickert, Lukas Heynck and Richard Lincoln
January 17, 2023

Neuri Christmas

Six-color fluorescence microscopy (5× STED + 1× confocal) in fixed rat hippocampal primary neurons enabled by combining conventional and HCage flurophores developed by Alexey Butkevich. The image shows inhibitory (Gephyrin, red) and excitatory (PSD95, blue) postsynaptic sites with the presynaptic counterpart (Bassoon, yellow) in the context of the membrane associated periodic actin cytoskeleton (beta-II-spectrin, white) and vesicular glutamate transporter 1 (vGLUT1, green). Pseudo volume labelling via actin labelling with phalloidin in cyan. Scale bar is 10 µm. From: Angel Rafael Cereceda Delgado
January 17, 2023

Through the Viral Lense

A false-color negative-stain electron micrograph of an uncultured giant virus particle found in a soil sample from Harvard Forest, MA, USA.
The sample site at Harvard Forest is warmed constantly at 5°C above ambient temperture to simulate warmer climate conditions.
In collaboration with Dr. Jeff Blanchard, we study the diversity of viruses by electron microscopy, metagenomics, and culturing to forecast temperature-related changes in the soil microbiome. From Ulli Mersdorf and Matthias Fischer
January 17, 2023

Pillar-like Nanostructures

Displayed is a sideview of a scanning electron microscope (SEM) image of a pillar-like nanostructure etched into a diamond surface. From: Louise Kaeswurm
January 17, 2023

Transmembrane Symmetry Breaking

Glowing DNA filaments inside of a synthetic cell. From: Kevin Jahnke, Maja Illig and Marlene Scheffold
January 17, 2023

Live Cellular Force Measurement

Live cellular force measurement. Green = cellular stress on the elastic substrate. Magenta = 200 nm fluorescent nanoparticles. From: Joel Christian
January 17, 2023

Combination of Live-Cell Labeling Tools

Four-color confocal image of a live U2OS cell stained using orthogonal xHTLs (MaP555-Hy5 - green, SiR-HSAm - gold), BG-JF585 (pink) and a SiR700-actin (blue) probe to label dHaloTag7-H2B (nucleus), TOM20-HaloTag7 (mitochondria surface) and LamP1-SNAPf-tag (lysosome). From: Julian Kompa
January 17, 2023

CRISPR/Cas9 Gene-edited Primary Hippocampal Neuron

Three-color confocal image of a primary hippocampal rat neuron (DIV3), endogenously GFP-labeled with ß-Actin (green), immunostained Cas9 (magenta) and DAPI (cyan). From: Jasmine Hubrich
January 17, 2023

Theeth Inside SEM Sample

Functionalized Au nanoparticles on functionalized Si wafer form islands that on this particular spot made this funny mouth looking pattern. From: Mariana Alarcon Correa
January 17, 2023

HaloTag Bringing Light into the Darkness

HaloTag protein covalently labeled with synthetic carbopyronine fluorophore. Atomic structure obtained via X-ray crystallography (PDB-ID: 6Y7B). Image rendered in blender. From: Jonas Wilhelm
January 17, 2023

Deformed Vesicle Membrane

Deformed vesicle (GUV) membrane with fluorescent lipids. From: Maja Illig
January 17, 2023

Pillar-like Nanostructure

January 17, 2023

Mitochondrial Network of a Neuronal Cell

Displayes is the mitochondrial network of a neuronal cell. Confocal images of mitochondria (Cox8A-HaloTag7) of cultured rat hippocampal neurons stained with SiR-Halo (500 nM). From: Julian Kompa
January 17, 2023

Mitochondrial network of a neuronal cell

Displayes is the mitochondrial network of a neuronal cell. Confocal images of mitochondria (Cox8A-HaloTag7) of cultured rat hippocampal neurons stained with SiR-Halo (500 nM). From: Julian Kompa
January 17, 2023

DNA-origami Medusa

Tinsule made from DNA. Each of our yellow DNA tinsules culminates in a red DNA origami. From: Marlene Scheffold, Kevin Jahnke and Maja Illig
January 17, 2023

Water-in-Oil Droplets

Water-in-oil droplets filled with DNA tiles and DNA filament fragments. From: Maja Illig
January 17, 2023

The Universe of Microcapsules

Taken by a confocal microscope, an assembly of Drug-loaded Extracellular-Matrixprotein Microcapsules is depicted. Due to fluorescently labeled proteins (red) and the autofluorescent drug inside (green) an overlay (yellow) is generated, which creates a beautiful micro-(capsule)universe. From: Roxana Pashapour
January 17, 2023

Pillar-like Nanostructure

Displayed is an overview of a scanning electron microscope (SEM) image of a pillar-like nanostructure etched into a diamond surface. From: Lousie Kaeswurm
January 17, 2023

Giant Unilamellar Vesicles Adhering to Each Other

Giant unilamellar vesicles adhering to each other
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