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BEGIN:VEVENT
DTSTAMP:20260509T200431Z
UID:https://www.mr.mpg.de/events/16109/10694
DTSTART:20181212T100000Z
DTEND:20181212T110000Z
CLASS:PUBLIC
CREATED:20181115T084442Z
DESCRIPTION: Title: DNA Bases beyond Watson and Crick T. Carell\, <i>Center
  for Integrative Protein Science at the</i> <i>Department of Chemistry\, L
 udwig Maximilians University\, Munich\, Butenandtstr. 5-13\, 81377</i>\; e
 -mail: thomas.carell@lmu.de\; www.carellgroup.de Keywords: Epigenetics\, o
 xidized pyrimidine bases\, mass spectrometry\, proteomics. <i> </i> Abstra
 ct: Epigenetic information is stored in the form of modified bases in the 
 genome. The positions and the kind of the base modifications determines th
 e identity of the corresponding cell. Setting and erasing of epigenetic im
 prints controls the complete development process starting from an omnipote
 nt stem cells and ending with an adult specialized cell. I am going to dis
 cuss results related to the function and distribution of the new epigeneti
 c bases 5-hydroxymethylcytosine (hmC)\, 5-formylcytosine (fC)\, 5-carboxyc
 ytosine (caC) and 5-hydroxymethyluracil (Scheme 1).<sup>[1]</sup> These nu
 cleobases seem to control epigenetic programming of cells and establish ge
 netic programmability. Synthetic routes to these new bases will be discuss
 ed that enable the preparation of oligonucleotides. The second part of the
  lecture will cover mass spectroscopic approaches to decipher the biologic
 al functions of the new bases.<sup>[2] </sup>In particular\, results from 
 quantitative mass spectrometry\, new covalent-capture proteomics mass spec
 trometry and isotope tracing techniques will be reported.<sup>[3] </sup>Fi
 nally I am dicussing potential präbiotic origins of modified bases<sup>[4
 ]</sup>.
LAST-MODIFIED:20181203T092952Z
LOCATION:MPI for Medical Research\, Room: Seminar Room C
ORGANIZER;CN=Prof. Dr. Kai Johnsson:mailto:pr@mpimf-heidelberg.mpg.de
SUMMARY:CB Seminar with Thomas Carell (LMU München): CB Seminar with Thoma
 s Carell (LMU München)
URL;VALUE=URI:https://www.mr.mpg.de/events/16109/10694
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