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BEGIN:VEVENT
DTSTAMP:20240329T060726Z
UID:https://www.mr.mpg.de/events/22413/10694
DTSTART:20191119T100000Z
DTEND:20191119T110000Z
CLASS:PUBLIC
CREATED:20191104T142458Z
DESCRIPTION: The detection of spectroscopically silent analytes in water is
often accomplished by utilization of reactive probes that form chromophor
ic analyte-dye conjugates. Unfortunately\, similar but distinctly differen
t analytes usually do not provide unique spectroscopic features\, such tha
t chromatographic separation steps have to be employed\, causing significa
nt additional costs and hinder applications. Supramolecular indicator-dye
displacement assays can overcome certain limitations of reactive-probes\,
e.g.\, they allow for an in situ detection of even non-funct
ionalizable analytes and are of great utility for reaction monitoring. How
ever\, their analyte differentiation capabilities are again restricted. He
re\, we present new strategies involving supramolecular sensing ensembles
that allow for improved analyte differentiation through spectroscopic fing
erprints. We show that this strategy is applicable to both non-covalent an
alyte-receptor binding schemes and to reactive-probe assays. As opposed to
contemporary sensing strategies\, our approach capitalizes on induced spe
ctroscopic changes that are resulting from\, (A) the direct “communicati
on” of the analyte with a suitable reporter dye in a confined receptor c
avity\, or (B) from the analyte-induced structural changes of supramolecul
ar dye-aggregates\, leading to an altered dye-dye “communication”.
LAST-MODIFIED:20191104T142500Z
LOCATION:MPI for Medical Research\, Room: Seminar Room C
ORGANIZER:Dr. Elisa D'Este
SUMMARY:ON Departmental Seminar with Frank Biedermann (KIT) on 'Supramolecu
lar Sensing Ensembles: More Information through Communication': ON Departm
ental Seminar with Frank Biedermann (KIT) on 'Supramolecular Sensing Ensem
bles: More Information through Communication'
URL:https://www.mr.mpg.de/events/22413/10694
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