Publications of Alfred Wittinghofer

Journal Article (87)

41.
Journal Article
Bock-Möbius, I.; Brune, M.; Wittinghofer, A.; Zimmermann, H.; Lebermann, R.; Dauvergne, M.-T.; Zimmermann, S.; Brandmeier, B.; Rösch, P.: Identification of valine/leucine/isoleucine and threonine/alanine/glycine proton-spin systems of Escherichia coli adenylate kinase by selective deuteration and selective protonation. Biochemical Journal 273 (2), pp. 311 - 316 (1991)
42.
Journal Article
Reinstein, J.; Schlichting, I.; Frech, M.; Goody, R. S.; Wittinghofer, A.: p21 with a phenylalanine 28----leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties. The Journal of Biological Chemistry 266 (26), pp. 17700 - 17706 (1991)
43.
Journal Article
Reinstein, J.; Vetter, I. R.; Schlichting, I.; Rösch, P.; Wittinghofer, A.; Goody, R. S.: Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases [Erratum to document cited in CA113(9):73603k]. Biochemistry 29 (48), p. 10864 - 10864 (1990)
44.
Journal Article
Reinstein, J.; Schlichting, I.; Wittinghofer, A.: Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli. Biochemistry 29 (32), pp. 7451 - 7459 (1990)
45.
Journal Article
Reinstein, J.; Vetter, I. R.; Schlichting, I.; Rösch, P.; Wittinghofer, A.; Goody, R. S.: Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases. Biochemistry 29 (32), pp. 7440 - 7450 (1990)
46.
Journal Article
Krengel, U.; Schlichting, I.; Scherer, A.; Schumann, R.; Frech, M.; John, J.; Kabsch, W.; Pai, E. F.; Wittinghofer, A.: Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell 62 (3), pp. 539 - 548 (1990)
47.
Journal Article
Schlichting, I.; Almo, S. C.; Rapp, G.; Wilson, K.; Petratos, K.; Lentfer, A.; Wittinghofer, A.; Kabsch, W.; Pai, E. F.; Petsko, G. A. et al.; Goody, R. S.: Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis. Nature 345 (6273), pp. 309 - 315 (1990)
48.
Journal Article
Frech, M.; Schlichting, I.; Wittinghofer, A.; Chardin, P.: Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli. Journal of Biological Chemistry 265 (11), pp. 6353 - 6359 (1990)
49.
Journal Article
Schlichting, I.; John, J.; Frech, M.; Chardin, P.; Wittinghofer, A.; Zimmermann, H.; Rösch, P.: Proton NMR studies of transforming and nontransforming H-ras p21 mutants. Biochemistry 29 (2), pp. 504 - 511 (1990)
50.
Journal Article
Schlichting, I.; Rapp, G.; John, J.; Wittinghofer, A.; Pai, E. F.; Goody, R. S.: Biochemical and crystallographic characterization of a complex of c-Ha-ras p21 and caged GTP with flash photolysis. Proceedings of the National Academy of Sciences of the United States of America 86 (20), pp. 7687 - 7690 (1989)
51.
Journal Article
Pai, E. F.; Kabsch, W.; Krengel, U.; Holmes, K. C.; John, J. J.; Wittinghofer, A.: Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature 341 (6239), pp. 209 - 214 (1989)
52.
Journal Article
John, J.; Schlichting, I.; Schiltz, E.; Rösch, P.; Wittinghofer, A.: C-terminal truncation of p21H preserves crucial kinetic and structural properties. The Journal of Biological Chemistry 264 (22), pp. 13086 - 13092 (1989)
53.
Journal Article
Reinstein, J.; Gilles, A.; Rose, T.; Wittinghofer, A.; Saint−Girons, I.; Barzu, O.; Surewicz, W. K.; Mantsch, H. H.: Structural and catalytic role of arginine 88 in Escherichia coli adenylate kinase as evidenced by chemical modification and site-directed mutagenesis. The Journal of Biological Chemistry 264 (14), pp. 8107 - 8112 (1989)
54.
Journal Article
Haase, G. H. W.; Brune, M.; Reinstein, J.; Pai, E. F.; Pingoud, A.; Wittinghofer, A.: Adenylate kinases from thermosensitive Escherichia coli strains. Journal of Molecular Biology (London) 207 (1), pp. 151 - 162 (1989)
55.
Journal Article
Scherer, A.; John, J.; Linke, R.; Goody, R. S.; Wittinghofer, A.; Pai, E. F.; Holmes, K. C.: Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues. Journal of Molecular Biology (London) 206 (1), pp. 257 - 259 (1989)
56.
Journal Article
Vetter, I. R.; Schlichting, I.; Wittinghofer, A.; Goody, R. S.; Rösch, P.: NMR studies of protein-nucleotide interactions: p21 and adenylate kinase. Bulletin of Magnetic Resonance 11 (3-4), pp. 203 - 209 (1989)
57.
Journal Article
Pingoud, A.; Wehrmann, M.; Pieper, U.; Gast, F.-U.; Urbanke, C.; Alves, J.; Feuerstein, J.; Wittinghofer, A.: Spectroscopic and hydrodynamic studies reveal structural differences in normal and transforming H-ras gene products. Biochemistry 27 (13), pp. 4735 - 4740 (1988)
58.
Journal Article
Reinstein, J.; Brune, M.; Wittinghofer, A.: Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli. Biochemistry 27 (13), pp. 4712 - 4720 (1988)
59.
Journal Article
Bock, I.; Reinstein, J.; Brune, M.; Wittinghofer, A.; Rösch, P.: Proton-nuclear magnetic resonance studies of the aromatic spin systems of Escherichia coli adenylate kinase. Journal of Molecular Biology (London) 200 (4), pp. 745 - 748 (1988)
60.
Journal Article
Schlichting, I.; Wittinghofer, A.; Rösch, P.: Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21. Biochemical and Biophysical Research Communications 150 (1), pp. 444 - 448 (1988)
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