Ausgewählte Referenzen


1.         Sommer, B., Kohler, M., Sprengel, R., and Seeburg, P.H. (1991) Rna Editing in Brain Controls a Determinant of Ion Flow in Glutamate-Gated Channels. Cell (67):  11-19.

2.         Brusa, R., Zimmermann, F., Koh, D.S., Feldmeyer, D., Gass, P., Seeburg, P.H., and Sprengel, R. (1995) Early-Onset Epilepsy and Postnatal Lethality Associated with an Editing-Deficient Glur-B Allele in Mice. Science (270):  1677-1680.

3.         Single, F.N., Rozov, A., Burnashev, N., Zimmermann, F., Hanley, D.F., Forrest, D., Curran, T., Jensen, V., Hvalby, O., Sprengel, R., and Seeburg, P.H. (2000) Dysfunctions in Mice by Nmda Receptor Point Mutations Nr1(N598q) and Nr1(N598r). J. Neurosci. (20):  2558-2566.

4.         Bannerman, D.M., Bus, T., Taylor, A., Sanderson, D.J., Schwarz, I., Jensen, V., Hvalby, O., Rawlins, J.N., Seeburg, P.H., and Sprengel, R. (2012) Dissecting Spatial Knowledge from Spatial Choice by Hippocampal Nmda Receptor Deletion. Nat. Neurosci. (15):  1153-1159.

5.         Krestel, H.E., Mayford, M., Seeburg, P.H., and Sprengel, R. (2001) A Gfp-Equipped Bidirectional Expression Module Well Suited for Monitoring Tetracycline-Regulated Gene Expression in Mouse. Nucleic Acids Res. (29):  E39.

6.         Krestel, H.E., Shimshek, D.R., Jensen, V., Nevian, T., Kim, J., Geng, Y., Bast, T., Depaulis, A., Schonig, K., Schwenk, F., Bujard, H., Hvalby, O., Sprengel, R., and Seeburg, P.H. (2004) A Genetic Switch for Epilepsy in Adult Mice. J. Neurosci. (24):  10568-10578.

7.         Niewoehner, B., Single, F.N., Hvalby, O., Jensen, V., Borgloh, S.M., Seeburg, P.H., Rawlins, J.N., Sprengel, R., and Bannerman, D.M. (2007) Impaired Spatial Working Memory but Spared Spatial Reference Memory Following Functional Loss of Nmda Receptors in the Dentate Gyrus. Eur. J. Neurosci. (25):  837-846.

8.         Chen, Y., Cao, L., Luo, C., Ditzel, D.A., Peter, J., and Sprengel, R. (2013) Range: Gene Transfer of Reversibly Controlled Polycistronic Genes. Mol Ther Nucleic Acids (2):  e85.

9.         Dogbevia, G.K., Marticorena-Alvarez, R., Bausen, M., Sprengel, R., and Hasan, M.T. (2015) Inducible and Combinatorial Gene Manipulation in Mouse Brain. Front. Cell. Neurosci. (9):  142.

10.       Dogbevia, G.K., Robetamanith, M., Sprengel, R., and Hasan, M.T. (2016) Flexible, Aav-Equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain. Mol Ther Nucleic Acids (5):  e309.

11.       Heinonen, A.M., Rahman, M., Dogbevia, G., Jakobi, H., Wolfl, S., Sprengel, R., and Schwaninger, M. (2014) Neuroprotection by Raav-Mediated Gene Transfer of Bone Morphogenic Protein 7. BMC Neurosci. (15):  38.

12.       Lissek, T., Obenhaus, H.A., Ditzel, D.A., Nagai, T., Miyawaki, A., Sprengel, R., and Hasan, M.T. (2016) General Anesthetic Conditions Induce Network Synchrony and Disrupt Sensory Processing in the Cortex. Front. Cell. Neurosci. (10):  64.

13.       Wallace, D., Zum Alten Borgloh, S., Astori, S., Yang, Y., Bausen, M., Kügler, S., Palmer, A., Tsien, R., Sprengel, R., Kerr, J., Denk, W., and Hasan, M. (2008) Single-Spike Detection in Vitro and in Vivo with a Genetic Ca2+ Sensor. Nat Meth (5):  797-804.

14.       Barkus, C., Feyder, M., Graybeal, C., Wright, T., Wiedholz, L., Izquierdo, A., Kiselycznyk, C., Schmitt, W., Sanderson, D.J., Rawlins, J.N., Saksida, L.M., Bussey, T.J., Sprengel, R., Bannerman, D., and Holmes, A. (2012) Do Glua1 Knockout Mice Exhibit Behavioral Abnormalities Relevant to the Negative or Cognitive Symptoms of Schizophrenia and Schizoaffective Disorder? Neuropharmacology (62):  1263-1272.

15.       Fitzgerald, P.J., Barkus, C., Feyder, M., Wiedholz, L.M., Chen, Y.C., Karlsson, R.M., Machado-Vieira, R., Graybeal, C., Sharp, T., Zarate, C., Harvey-White, J., Du, J., Sprengel, R., Gass, P., Bannerman, D., and Holmes, A. (2010) Does Gene Deletion of Ampa Glua1 Phenocopy Features of Schizoaffective Disorder? Neurobiol. Dis. (40):  608-621.

16.       Inta, D., Monyer, H., Sprengel, R., Meyer-Lindenberg, A., and Gass, P. (2010) Mice with Genetically Altered Glutamate Receptors as Models of Schizophrenia: A Comprehensive Review. Neurosci. Biobehav. Rev. (34):  285-294.

17.       Sanderson, D.J., Good, M.A., Seeburg, P.H., Sprengel, R., Rawlins, J.N., and Bannerman, D.M. (2008) The Role of the Glur-a (Glur1) Ampa Receptor Subunit in Learning and Memory. Prog. Brain Res. (169):  159-178.

18.       Wiedholz, L.M., Owens, W.A., Horton, R.E., Feyder, M., Karlsson, R.M., Hefner, K., Sprengel, R., Celikel, T., Daws, L.C., and Holmes, A. (2008) Mice Lacking the Ampa Glur1 Receptor Exhibit Striatal Hyperdopaminergia and 'Schizophrenia-Related' Behaviors. Mol. Psychiatry (13):  631-640.

19.       Shimshek, D.R., Jensen, V., Celikel, T., Geng, Y., Schupp, B., Bus, T., Mack, V., Marx, V., Hvalby, O., Seeburg, P.H., and Sprengel, R. (2006) Forebrain-Specific Glutamate Receptor B Deletion Impairs Spatial Memory but Not Hippocampal Field Long-Term Potentiation. J. Neurosci. (26):  8428-8440.

20.       Zamanillo, D., Sprengel, R., Hvalby, O., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K.M., Koster, H.J., Borchardt, T., Worley, P., Lubke, J., Frotscher, M., Kelly, P.H., Sommer, B., Andersen, P., Seeburg, P.H., and Sakmann, B. (1999) Importance of Ampa Receptors for Hippocampal Synaptic Plasticity but Not for Spatial Learning. Science (284):  1805-1811.

21.       Berkel, S., Marshall, C.R., Weiss, B., Howe, J., Roeth, R., Moog, U., Endris, V., Roberts, W., Szatmari, P., Pinto, D., Bonin, M., Riess, A., Engels, H., Sprengel, R., Scherer, S.W., and Rappold, G.A. (2010) Mutations in the Shank2 Synaptic Scaffolding Gene in Autism Spectrum Disorder and Mental Retardation. Nat. Genet. (42):  489-491.

22.       Sprengel, R., Ionotropic Glutamate Receptors, in Neuroscience in the 21st Century - from Basic to Clinical, D.W. Pfaff, Editor. 2013, Springer: Ney York. p. 59-80.

23.       Kiselycznyk, C., Jury, N.J., Halladay, L.R., Nakazawa, K., Mishina, M., Sprengel, R., Grant, S.G., Svenningsson, P., and Holmes, A. (2015) Nmda Receptor Subunits and Associated Signaling Molecules Mediating Antidepressant-Related Effects of Nmda-Glun2b Antagonism. Behav. Brain Res. (287):  89-95.

24.       Freudenberg, F., Resnik, E., Kolleker, A., Celikel, T., Sprengel, R., and Seeburg, P.H. (2016) Hippocampal Glua1 Expression in Gria1-/- Mice Only Partially Restores Spatial Memory Performance Deficits. Neurobiol. Learn. Mem. (135):  83 - 90.

25.       Weber, T., Vogt, M.A., Gartside, S.E., Berger, S.M., Lujan, R., Lau, T., Herrmann, E., Sprengel, R., Bartsch, D., and Gass, P. (2015) Adult Ampa Glua1 Receptor Subunit Loss in 5-Ht Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-Ht Neuronal Activity. Neuropsychopharmacology (40):  1471-1484.

26.       Vogt, M.A., Elkin, H., Pfeiffer, N., Sprengel, R., Gass, P., and Inta, D. (2014) Impact of Adolescent Glua1 Ampa Receptor Ablation in Forebrain Excitatory Neurons on Behavioural Correlates of Mood Disorders. Eur. Arch. Psychiatry Clin. Neurosci. (254):  625–629.

27.       Inta, D., Vogt, M.A., Elkin, H., Weber, T., Lima-Ojeda, J.M., Schneider, M., Luoni, A., Riva, M.A., Gertz, K., Hellmann-Regen, J., Kronenberg, G., Meyer-Lindenberg, A., Sprengel, R., and Gass, P. (2014) Phenotype of Mice with Inducible Ablation of Glua1 Ampa Receptors During Late Adolescence: Relevance for Mental Disorders. Hippocampus (24):  424-435.

28.       Freudenberg, F., Marx, V., Seeburg, P.H., Sprengel, R., and Celikel, T. (2013) Circuit Mechanisms of Glua1-Dependent Spatial Working Memory. Hippocampus (23):  1359-1366.

29.       Freudenberg, F., Marx, V., Mack, V., Layer, L.E., Klugmann, M., Seeburg, P.H., Sprengel, R., and Celikel, T. (2013) Glua1 and Its Pdz-Interaction: A Role in Experience-Dependent Behavioral Plasticity in the Forced Swim Test. Neurobiol. Dis. (52):  160-167.

30.       Sanderson, D.J., Lee, A., Sprengel, R., Seeburg, P.H., Harrison, P.J., and Bannerman, D.M. (2017) Altered Balance of Excitatory and Inhibitory Learning in a Genetically Modified Mouse Model of Glutamatergic Dysfunction Relevant to Schizophrenia. Sci. Rep. (7):  1765.

31.       Boerner, T., Bygrave, A., Chen, J., Fernando, A., Jackson, S., Barkus, C., Sprengel, R., Seeburg, P.H., Harrison, P.J., Gilmour, G., Bannerman, D.M., and Sanderson, D.J. (2017) The Group Ii Metabotropic Glutamate Receptor Agonist Ly354740 and the D2 Receptor Antagonist Haloperidol Reduce Locomotor Hyperactivity but Fail to Rescue Spatial Working Memory in Glua1 Knockout Mice. Eur. J. Neurosci.

32.       Lang, E., Mallien, A.S., Vasilescu, A.N., Hefter, D., Luoni, A., Riva, M.A., Borgwardt, S., Sprengel, R., Lang, U.E., Gass, P., and Inta, D. (2017) Molecular and Cellular Dissection of Nmda Receptor Subtypes as Antidepressant Targets. Neurosci. Biobehav. Rev.  [Epub ahead of print].

33.       Bygrave, A.M., Masiulis, S., Nicholson, E., Berkemann, M., Barkus, C., Sprengel, R., Harrison, P.J., Kullmann, D.M., Bannerman, D.M., and Katzel, D. (2016) Knockout of Nmda-Receptors from Parvalbumin Interneurons Sensitizes to Schizophrenia-Related Deficits Induced by Mk-801. Transl Psychiatry (6):  e778.

34.       Taylor, A.M., Bus, T., Sprengel, R., Seeburg, P.H., Rawlins, J.N., and Bannerman, D.M. (2014) Hippocampal Nmda Receptors Are Important for Behavioural Inhibition but Not for Encoding Associative Spatial Memories. Philos. Trans. R. Soc. Lond. B Biol. Sci. (369):  20130149.

35.       Bannerman, D.M., Sprengel, R., Sanderson, D.J., McHugh, S.B., Rawlins, J.N., Monyer, H., and Seeburg, P.H. (2014) Hippocampal Synaptic Plasticity, Spatial Memory and Anxiety. Nat. Rev. Neurosci. (15):  181-192.

36.       Shimshek, D.R., Bus, T., Schupp, B., Jensen, V., Marx, V., Layer, L.E., Kohr, G., and Sprengel, R. (2017) Different Forms of Ampa Receptor Mediated Ltp and Their Correlation to the Spatial Working Memory Formation. Front. Mol. Neurosci. (10):  214.

37.       Sprengel, R., Eltokhi, A., and Single, F.N., Gene Targeted Mice with Conditional Knock-in (-out) of Nmdar Mutations, in Nmda Receptors. Methods in Molecular Biology, Burnashev N. and S. P., Editors. 2017. p. 201-230.

38.       Berkel, S., Tang, W., Trevino, M., Vogt, M., Obenhaus, H.A., Gass, P., Scherer, S.W., Sprengel, R., Schratt, G., and Rappold, G.A. (2012) Inherited and De Novo Shank2 Variants Associated with Autism Spectrum Disorder Impair Neuronal Morphogenesis and Physiology. Hum. Mol. Genet. (21):  344-357.

39.       Mack, V., Burnashev, N., Kaiser, K.M., Rozov, A., Jensen, V., Hvalby, O., Seeburg, P.H., Sakmann, B., and Sprengel, R. (2001) Conditional Restoration of Hippocampal Synaptic Potentiation in Glur-a-Deficient Mice. Science (292):  2501-2504.

40.       Enger, R., Dukefoss, D.B., Tang, W., Pettersen, K.H., Bjornstad, D.M., Helm, P.J., Jensen, V., Sprengel, R., Vervaeke, K., Ottersen, O.P., and Nagelhus, E.A. (2017) Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice. Cereb. Cortex (27):  24-33.

41.       Tang, W., Szokol, K., Jensen, V., Enger, R., Trivedi, C.A., Hvalby, O., Helm, P.J., Looger, L.L., Sprengel, R., and Nagelhus, E.A. (2015) Stimulation-Evoked Ca2+ Signals in Astrocytic Processes at Hippocampal Ca3-Ca1 Synapses of Adult Mice Are Modulated by Glutamate and Atp. J. Neurosci. (35):  3016-3021.

42.       Enger, R., Tang, W., Vindedal, G.F., Jensen, V., Johannes Helm, P., Sprengel, R., Looger, L.L., and Nagelhus, E.A. (2015) Dynamics of Ionic Shifts in Cortical Spreading Depression. Cereb. Cortex (25):  4469-4476. .

43.       Tang, W., Ehrlich, I., Wolff, S.B.E., Michalski, A.-M., Wölfl, S., Hasan, M.T., Lüthi, A., and Sprengel, R. (2009) Faithful Expression of Multiple Proteins Via 2a-Peptide Self-Processing: A Versatile and Reliable Method for Manipulating Brain Circuits. J. Neurosci. (29):  8621-8629.

44.       Obenhaus, H.A., Rozov, A., Bertocchi, I., Tang, W., Kirsch, J., Betz, H., and Sprengel, R. (2016) Causal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors. Front. Mol. Neurosci. (9):  75.

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