
Single Molecule Sensing
Research Group Leader: Viktorija Glembockyte
In our group, we are excited about the ability to visualize and sense single biomolecules using both the tools of DNA nanotechnology and single-molecule fluorescence imaging. The Single Molecule Sensing Group has begun its work in January 2025. If you would like to be part of the team, get in touch!
Our mission
We are dedicated to unraveling the intricate details of molecular processes at the single-molecule level. By harnessing the power of DNA nanotechnology and advanced microscopy techniques, we aim to gain a deeper understanding and control over these fundamental biological interactions.
Our research
- DNA nanotechnology and Single-Molecule Fluorescence Imaging: We leverage the precision of DNA nanotechnology to even more precisely position molecules and arrange functions on the nanoscale to build new nanosensors and nanodevices. Our single-molecule fluorescence imaging techniques allow us to study and visualize them with unparalleled sensitivity and resolution.
- Superresolution imaging and Nanoscale Stability: We employ superresolution imaging methods and develop novel fluorescence-based tools to investigate the stability and addressability of nanoscale devices. Our goal is to enhance their robustness and reliability in complex biochemical environments.
- Single Molecule Photophysics and DNA nanotechnology: We conduct in depth mechanistic studies on photophysical properties of fluorescence labels to optimize their performance in high-end imaging applications. Additionally, we utilize the versatility of DNA nanotechnology to develop new imaging tools.
The current topics include:
- Modular and tunable single-molecule sensors
- Proteolytic activity sensors
- Nanoscale stability and addressability of DNA nanodevices
- Nanoscale clustering and avidity
- Photostabilization and photoswitching strategies
Join our team!
We are currently looking for new team members from diverse backgrounds, including biophysics, chemistry, biochemistry, nanotechnology, and similar. If you share our passion for single-molecule sensing and are eager to join a collaborative and interdisciplinary team, don't hesitate to get in touch! Please send your application to Viktorija Glembockyte including a CV, a short cover letter explaining your background, motivation and current as well as future research interests.
Some highlighted works:
Photo credits: Viktorija Glembockyte, LMU Press Office