Single Molecule Sensing
Research Group Leader: Viktorija Glembockyte
In our group, we are excited about the ability to visualize and sense single biomolecules using both the tools of DNA nanotechnology and single-molecule fluorescence imaging.
Our mission
We are dedicated to unraveling the intricate details of molecular processes at the single-molecule level. By harnessing the power of DNA nanotechnology and advanced microscopy techniques, we aim to gain a deeper understanding and control over these fundamental biological interactions.
Our research
- DNA nanotechnology and Single-Molecule Fluorescence Imaging: We leverage the precision of DNA nanotechnology to even more precisely position molecules and arrange functions on the nanoscale to build new nanosensors and nanodevices. Our single-molecule fluorescence imaging techniques allow us to study and visualize them with unparalleled sensitivity and resolution.
- Superresolution imaging and Nanoscale Stability: We employ superresolution imaging methods and develop novel fluorescence-based tools to investigate the stability and addressability of nanoscale devices. Our goal is to enhance their robustness and reliability in complex biochemical environments.
- Single Molecule Photophysics and DNA nanotechnology: We conduct in depth mechanistic studies on photophysical properties of fluorescence labels to optimize their performance in high-end imaging applications. Additionally, we utilize the versatility of DNA nanotechnology to develop new imaging tools.
The current topics include:
- Modular and tunable single-molecule sensors
- Proteolytic activity sensors
- Nanoscale stability and addressability of DNA nanodevices
- Nanoscale clustering and avidity
- Photostabilization and photoswitching strategies
Some highlighted works:
Photo credits: Viktorija Glembockyte, LMU Press Office