Publikationen von Alfred Wittinghofer

Kühnel, K.; Veltel, S.; Schlichting, I.; Wittinghofer, A.: Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Structure 14 (2), S. 367 - 378 (2006)

Kühnel, K.; Jarchau, T.; Wolf, E.; Schlichting, I.; Walter, U.; Wittinghofer, A.; Strelkov, S. V.: The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proceedings of the National Academy of Sciences of the United States of America 101 (49), S. 17027 - 17032 (2004)

Scheffzek, K.; Grünewald, P.; Wohlgemuth, S.; Kabsch, W.; Tu, H.; Wigler, M.; Wittinghofer, A.; Herrmann, C.: The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure 9 (11), S. 1043 - 1050 (2001)

Geyer, M.; Assheuer, R.; Klebe, C.; Kuhlmann, J.; Becker, J.; Wittinghofer, A.; Kalbitzer, H. R.: Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1. Biochemistry 38 (35), S. 11250 - 11260 (1999)

Ahmadian, M. R.; Zor, T.; Vogt, D.; Kabsch, W.; Selinger, Z.; Wittinghofer, A.; Scheffzek, K.: Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proceedings of the National Academy of Sciences of the United States of America 96 (12), S. 7065 - 7070 (1999)

Vetter, I. R.; Linnemann, T.; Wohlgemuth, S.; Geyer, M.; Kalbitzer, H. R.; Herrmann, C.; Wittinghofer, A.: Structural and biochemical analysis on Ras-effector signaling via RalGDS. FEBS Letters 451 (2), S. 175 - 180 (1999)

Linnemann, T.; Geyer, M.; Jaitner, B. K.; Block, C.; Kalbitzer, H. R.; Wittinghofer, A.; Herrmann, C.: Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. The Journal of Biological Chemistry 274 (19), S. 13556 - 13562 (1999)

Scheffzek, K.; Ahmadian, M. R.; Wiesmüller, L.; Kabsch, W.; Stege, P.; Schmitz, F.; Wittinghofer, A.: Structural analysis of the GAP-related domain from neurofibromin and its implications. The EMBO Journal; Nature Publishing Group 17 (15), S. 4313 - 4327 (1998)

Geyer, M.; Wittinghofer, A.: GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Current Opinion in Structural Biology 7 (6), S. 786 - 792 (1997)

Ahmadian, M. R.; Stege, P.; Scheffzek, K.; Wittinghofer, A.: Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature structural biology 4 (9), S. 686 - 689 (1997)

Geyer, M.; Herrmann, C.; Wohlgemuth, S.; Wittinghofer, A.; Kalbitzer, H. R.: Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. Nature structural biology 4 (9), S. 694 - 699 (1997)

Scheffzek, K.; Ahmadian, M. R.; Kabsch, W.; Wiesmüller, L.; Lautwein, A.; Schmitz, F.; Wittinghofer, A.: The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277 (5324), S. 333 - 338 (1997)

Wittinghofer, A.; Scheffzek, K.; Ahmadian, M. R.: The interaction of Ras with GTPase-activating proteins. FEBS Letters 410 (1), S. 63 - 67 (1997)

Schweins, T.; Scheffzek, K.; Assheuer, R.; Wittinghofer, A.: The role of the metal ion in the p21^rascatalysed GTP-hydrolysis: Mn²⁺ versus Mg²⁺. Journal of Molecular Biology (London) 266 (4), S. 847 - 856 (1997)

Scheffzek, K.; Lautwein, A.; Scherer, A.; Franken, S.; Wittinghofer, A.: Crystallization and preliminary X-ray crystallographic study of the Ras-GTPase-activating domain of human p120GAP. Proteins: Structure, Function, and Genetics 27 (2), S. 315 - 318 (1997)

Schweins, T.; Geyer, M.; Kalbitzer, H. R.; Wittinghofer, A.; Warshel, A.: Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras. Biochemistry 35 (45), S. 14225 - 14231 (1996)

Geyer, M.; Schweins, T.; Herrmann, C.; Prisner, T.; Wittinghofer, A.; Kalbitzer, H. R.: Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP. Biochemistry 35 (32), S. 10308 - 10320 (1996)

Scheffzek, K.; Lautwein, A.; Kabsch, W.; Ahmadian, M. R.; Wittinghofer, A.: Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature 384, S. 591 - 596 (1996)

Scheidig, A. J.; Franken, S. M.; Corrie, J. E. T.; Reid, G. P.; Wittinghofer, A.; Pai, E. F.; Goody, R. S.: X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and Mant dGppNHp. Journal of Molecular Biology (London) 253 (1), S. 132 - 150 (1995)

Wiesmüller, L.; Scheffzek, K.; Kliche, W.; Goody, R. S.; Wittinghofer, A.; Reinstein, J.: Crystallization and preliminary X-ray analysis of UMP/CMP-kinase from Dictyostelium discoideum with the specific bisubstrate inhibitor P1-(adenosine 5′)-P5-(uridine 5′)-pentaphosphate (UP5A). FEBS Letters 363 (1), S. 22 - 24 (1995)