Publikationen von Klaus Scheffzek

Corsini, L.; Hothorn, M.; Stier, G.; Rybin, V.; Scheffzek, K.; Gibson, T. J.; Sattler, M.: Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60. The Journal of Biological Chemistry 284 (1), S. 630 - 639 (2009)

Corsini, L.; Hothorn, M.; Scheffzek, K.; Sattler, M.; Stier, G.: Thioredoxin as a fusion tag for carrier-driven crystallization. Protein Science 17 (12), S. 2070 - 2079 (2008)

Bonneau, F.; D Angelo, I.; Welti, S.; Stier, G.; Ylänne, J.; Scheffzek, K.: Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein. Acta Crystallographica Section D-Biological Crystallography 60 (2), S. 2364 - 2367 (2004)

Hothorn, M.; Bonneau, F.; Stier, G.; Greinerb, S.; Scheffzek, K.: Bacterial expression, purification and preliminary X-ray crystallographic characterization of the invertase inhibitor Nt-CIF from tobacco. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 59 (12), S. 2279 - 2282 (2003)

Stumber, M.; Geyer, M.; Graf, R.; Kalbitzer, H. R.; Scheffzek, K.; Haeberlen, U.: Observation of slow dynamic exchange processes in Ras protein crystals by ³¹P solid state NMR spectroscopy. Journal of Molecular Biology (London) 323 (5), S. 899 - 907 (2002)

Scheffzek, K.; Grünewald, P.; Wohlgemuth, S.; Kabsch, W.; Tu, H.; Wigler, M.; Wittinghofer, A.; Herrmann, C.: The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure 9 (11), S. 1043 - 1050 (2001)

Scheffzek, K.; Stephan, I.; Jensen, O. N.; Illenberger, D.; Gierschik, P.: The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nature structural biology 7 (2), S. 122 - 126 (2000)

Ahmadian, M. R.; Zor, T.; Vogt, D.; Kabsch, W.; Selinger, Z.; Wittinghofer, A.; Scheffzek, K.: Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proceedings of the National Academy of Sciences of the United States of America 96 (12), S. 7065 - 7070 (1999)

Scheffzek, K.; Ahmadian, M. R.; Wiesmüller, L.; Kabsch, W.; Stege, P.; Schmitz, F.; Wittinghofer, A.: Structural analysis of the GAP-related domain from neurofibromin and its implications. The EMBO Journal; Nature Publishing Group 17 (15), S. 4313 - 4327 (1998)

Ahmadian, M. R.; Stege, P.; Scheffzek, K.; Wittinghofer, A.: Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature structural biology 4 (9), S. 686 - 689 (1997)

Scheffzek, K.; Ahmadian, M. R.; Kabsch, W.; Wiesmüller, L.; Lautwein, A.; Schmitz, F.; Wittinghofer, A.: The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277 (5324), S. 333 - 338 (1997)

Wittinghofer, A.; Scheffzek, K.; Ahmadian, M. R.: The interaction of Ras with GTPase-activating proteins. FEBS Letters 410 (1), S. 63 - 67 (1997)

Schweins, T.; Scheffzek, K.; Assheuer, R.; Wittinghofer, A.: The role of the metal ion in the p21^rascatalysed GTP-hydrolysis: Mn²⁺ versus Mg²⁺. Journal of Molecular Biology (London) 266 (4), S. 847 - 856 (1997)

Scheffzek, K.; Lautwein, A.; Scherer, A.; Franken, S.; Wittinghofer, A.: Crystallization and preliminary X-ray crystallographic study of the Ras-GTPase-activating domain of human p120GAP. Proteins: Structure, Function, and Genetics 27 (2), S. 315 - 318 (1997)

Scheffzek, K.; Kliche, W.; Wiesmüller, L.; Reinstein, J.: Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-Adenosyl)-P5- (5'-Uridyl) Pentaphosphate (UP5A ) and Mg2+ at 2.2 Å: implications for water-mediated specificity. Biochemistry 35 (30), S. 9716 - 9727 (1996)

Scheffzek, K.; Lautwein, A.; Kabsch, W.; Ahmadian, M. R.; Wittinghofer, A.: Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature 384, S. 591 - 596 (1996)

Wiesmüller, L.; Scheffzek, K.; Kliche, W.; Goody, R. S.; Wittinghofer, A.; Reinstein, J.: Crystallization and preliminary X-ray analysis of UMP/CMP-kinase from Dictyostelium discoideum with the specific bisubstrate inhibitor P1-(adenosine 5′)-P5-(uridine 5′)-pentaphosphate (UP5A). FEBS Letters 363 (1), S. 22 - 24 (1995)

Scheffzek, K.; Klebe, C.; Fritz-Wolf, K.; Kabsch, W.; Wittinghofer, A.: Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form. Nature 374 (6520), S. 378 - 381 (1995)

Schweins, T.; Geyer, M.; Scheffzek, K.; Warshel, A.; Kalbitzer, H. R.; Wittinghofer, A.: Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nature Structural and Molecular Biology 2 (1), S. 36 - 44 (1995)

Scheffzek, K.; Kabsch, W.; Schlichting, I.; Pai, E. F.; Lautwein, A.; Frech, M.; Wittinghofer, A.; Goody, R. S.: Crystallization and preliminary X-ray structure analysis of thermally unstable p21H-ras guanosine complexes. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 50 (4), S. 521 - 526 (1994)