In vivo acetylcholine receptor dynamics at neuromuscular junctions
Research report (imported) 2010 - Max Planck Institute for Medical Research
Synaptogenesis and synaptic plasticity require interactions between pre- and postsynaptic components. The neuromuscular synapse as model and genetically manipulated mice were used to study the dynamics of acetylcholine receptors. Direct in vivo analysis shows how newly synthesized receptors are integrated into the existing synapse and how receptor stability changes when muscle is inactivated by innervation.