Publications of Alfred Wittinghofer

Journal Article (85)

21.
Journal Article
Scheffzek, K.; Klebe, C.; Fritz-Wolf, K.; Kabsch, W.; Wittinghofer, A.: Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form. Nature 374 (6520), pp. 378 - 381 (1995)
22.
Journal Article
Rensland, H.; John, J.; Linke, R.; Simon, I.; Schlichting, I.; Wittinghofer, A.; Goody, R. S.: Substrate and product structural requirements for binding of nucleotides to H-ras p21: the mechanism of discrimination between guanosine and adenosine nucleotides. Biochemistry 34 (2), pp. 593 - 599 (1995)
23.
Journal Article
Schweins, T.; Geyer, M.; Scheffzek, K.; Warshel, A.; Kalbitzer, H. R.; Wittinghofer, A.: Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nature Structural and Molecular Biology 2 (1), pp. 36 - 44 (1995)
24.
Journal Article
Scheffzek, K.; Kabsch, W.; Schlichting, I.; Pai, E. F.; Lautwein, A.; Frech, M.; Wittinghofer, A.; Goody, R. S.: Crystallization and preliminary X-ray structure analysis of thermally unstable p21H-ras guanosine complexes. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 50 (4), pp. 521 - 526 (1994)
25.
Journal Article
Scheidig, A. J.; Sanchez-Llorente, A.; Lautwein, A.; Pai, E. F.; Corrie, J. E. T.; Reid, G. P.; Wittinghofer, A.; Goody, R. S.: Crystallographic studies on p21H-ras using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 50 (4), pp. 512 - 520 (1994)
26.
Journal Article
Franken, S. M.; Scheidig, A. J.; Krengel, U.; Rensland, H.; Lautwein, A.; Geyer, M.; Scheffzek, K.; Goody, R. S.; Kalbitzer, H. R.; Pai, E. F. et al.; Wittinghofer, A.: Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry 32 (33), pp. 8411 - 8420 (1993)
27.
Journal Article
John, J.; Rensland, H.; Schlichting, I.; Vetter, I. R.; Borasio, G. D.; Goody, R. S.; Wittinghofer, A.: Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras. The Journal of Biological Chemistry 268 (2), pp. 923 - 929 (1993)
28.
Journal Article
Scheidig, A. J.; Pai, E. F.; Schlichting, I.; Corrie, J. E. T.; Reid, G. P.; Wittinghofer, A.; Goody, R. S.; Liljas, A.; Moffat, K.: Time-resolved crystallography on H-ras p21. Philosophical Transactions of the Royal Society A 340 (1657), pp. 263 - 272 (1992)
29.
Journal Article
Wittinghofer, A.: Three-dimensional structure of p21H-ras and its implications. Seminars in Cancer Biology 3, pp. 189 - 198 (1992)
30.
Journal Article
Wolber, V.; Maeda, K.; Schumann, R.; Brandmeier, B.; Wiesmüller, L.; Wittinghofer, A.: A universal expression-purification system based on the coiled-coil interaction of myosin heavy chain. Nature Biotechnology 10, pp. 900 - 904 (1992)
31.
Journal Article
Serth, J.; Weber, W.; Frech, M.; Wittinghofer, A.; Pingoud, A.: Binding of the h-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro. Biochemistry 31 (28), pp. 6361 - 6365 (1992)
32.
Journal Article
Mistou, M.-Y.; Jacquet, E.; Poullet, P.; Rensland, H.; Gideon, P.; Schlichting, I.; Wittinghofer, A.; Parmeggiani, A.: Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator. The EMBO Journal 11 (7), pp. 2391 - 2397 (1992)
33.
Journal Article
Müller, O.; French, M.; Gideon, P.; Wittinghofer, A.; Schwarz, M.: Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice. Oncogene 7 (7), pp. 1407 - 1412 (1992)
34.
Journal Article
Foley, C. K.; Pedersen, L. G.; Charifson, P. S.; Darden, T. A.; Wittinghofer, A.; Pai, E. F.; Anderson, M. W.: Simulation of the solution structure of the H-ras p21-GTP complex. Biochemistry 31 (21), pp. 4951 - 4959 (1992)
35.
Journal Article
Wiesmüller, L.; Wittinghofer, A.: Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue. The Journal of Biological Chemistry 267 (15), pp. 10207 - 10210 (1992)
36.
Journal Article
Gideon, P.; John, J.; Frech, M.; Lautwein, A.; Clark, R.; Scheffler, J. E.; Wittinghofer, A.: Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. Molecular and Cellular Biology (Washington, DC) 12 (5), pp. 2050 - 2056 (1992)
37.
Journal Article
Wolber, V.; Rensland, H.; Brandmeier, B.; Sagemann, M.; Hoffmann, R.; Kalbitzer, H. R.; Wittinghofer, A.: Expression, purification and biochemical characterisation of the human immunodeficiency virus 1 nef gene product. European Journal of Biochemistry 205 (3), pp. 1115 - 1121 (1992)
38.
Journal Article
Goody, R. S.; Pai, E. F.; Schlichting, I.; Rensland, H.; Scheideg, A.; Franken, S.; Wittinghofer, A.: Studies on the structure and mechanism of H-ras p21. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 336 (1276), pp. 3 - 11 (1992)
39.
Journal Article
Hahnel, C.; Gottmann, K.; Wittinghofer, A.; Lux, D.: P21ras oncogene protein selectively increases low-voltage-activated Ca2+ current density in embryonic chick dorsal root ganglion neurons. European Journal of Neuroscience: European Neuroscience Association 4 (4), pp. 361 - 368 (1992)
40.
Journal Article
Wittinghofer, A.; Krengel, U.; John, J.; Reinstein, J.; Frech, M.; Schlichting, I.; Goody, R. S.; Kabsch, W.; Pai, E. F.: 3D-structure and properties of wildtype and mutant H-Ras encoded P21. Biological Chemistry Hoppe-Seyler 372 (9), pp. 780 - 781 (1991)
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