Publications of Alfred Wittinghofer
All genres
Journal Article (87)
21.
Journal Article
374 (6520), pp. 378 - 381 (1995)
Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form. Nature 22.
Journal Article
34 (2), pp. 593 - 599 (1995)
Substrate and product structural requirements for binding of nucleotides to H-ras p21: the mechanism of discrimination between guanosine and adenosine nucleotides. Biochemistry 23.
Journal Article
2 (1), pp. 36 - 44 (1995)
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nature Structural and Molecular Biology 24.
Journal Article
50 (4), pp. 521 - 526 (1994)
Crystallization and preliminary X-ray structure analysis of thermally unstable p21H-ras guanosine complexes. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 25.
Journal Article
50 (4), pp. 512 - 520 (1994)
Crystallographic studies on p21H-ras using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 26.
Journal Article
32 (33), pp. 8411 - 8420 (1993)
Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry 27.
Journal Article
268 (2), pp. 923 - 929 (1993)
Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras. The Journal of Biological Chemistry 28.
Journal Article
340 (1657), pp. 263 - 272 (1992)
Time-resolved crystallography on H-ras p21. Philosophical Transactions of the Royal Society A 29.
Journal Article
3, pp. 189 - 198 (1992)
Three-dimensional structure of p21H-ras and its implications. Seminars in Cancer Biology 30.
Journal Article
10, pp. 900 - 904 (1992)
A universal expression-purification system based on the coiled-coil interaction of myosin heavy chain. Nature Biotechnology 31.
Journal Article
31 (28), pp. 6361 - 6365 (1992)
Binding of the h-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro. Biochemistry 32.
Journal Article
11 (7), pp. 2391 - 2397 (1992)
Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator. The EMBO Journal 33.
Journal Article
7 (7), pp. 1407 - 1412 (1992)
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice. Oncogene 34.
Journal Article
31 (21), pp. 4951 - 4959 (1992)
Simulation of the solution structure of the H-ras p21-GTP complex. Biochemistry 35.
Journal Article
267 (15), pp. 10207 - 10210 (1992)
Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue. The Journal of Biological Chemistry 36.
Journal Article
12 (5), pp. 2050 - 2056 (1992)
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. Molecular and Cellular Biology (Washington, DC) 37.
Journal Article
205 (3), pp. 1115 - 1121 (1992)
Expression, purification and biochemical characterisation of the human immunodeficiency virus 1 nef gene product. European Journal of Biochemistry 38.
Journal Article
336 (1276), pp. 3 - 11 (1992)
Studies on the structure and mechanism of H-ras p21. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 39.
Journal Article
4 (4), pp. 361 - 368 (1992)
P21ras oncogene protein selectively increases low-voltage-activated Ca2+ current density in embryonic chick dorsal root ganglion neurons. European Journal of Neuroscience: European Neuroscience Association 40.
Journal Article
372 (9), pp. 780 - 781 (1991)
3D-structure and properties of wildtype and mutant H-Ras encoded P21. Biological Chemistry Hoppe-Seyler