Publications of Max J. Cryle

Brieke, C.; Tarnawski, M.; Greule, A.; Cryle, M. J.: Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach. Journal of Inorganic Biochemistry 185, pp. 43 - 51 (2018)

Peschke, M.; Brieke, C.; Goode, R. J. A.; Schittenhelm, R. B.; Cryle, M.: Chlorinated glycopeptide antibiotic peptide precursors improve cytochrome P450-catalyzed cyclization cascade efficiency. Biochemistry 56 (9), pp. 1239 - 1247 (2017)

Ulrich, V.; Cryle, M.: SNaPe: a versatile method to generate multiplexed protein fusions using synthetic linker peptides for in vitro applications. Journal of Peptide Science 23 (1), pp. 16 - 27 (2017)

Ulrich, V.; Brieke, C.; Cryle, M.: Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934. Beilstein Journal of Organic Chemistry 12, pp. 2849 - 2864 (2016)

Brieke, C.; Yim, G.; Peschke, M.; Wright, G. D.; Cryle, M. J.: Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates. Chemical Communications 52 (94), pp. 13679 - 13682 (2016)

Ulrich, V.; Peschke, M.; Brieke, C.; Cryle, M.: More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH. Molecular BioSystems 12 (10), pp. 2992 - 3004 (2016)

Peschke, M.; Brieke, C.; Cryle, M. J.: F-O-G ring formation in glycopeptide antibiotic biosynthesis is catalysed by OxyE. Scientific Reports 6, 35584, pp. 1 - 9 (2016)

Peschke, M.; Haslinger, K.; Brieke, C.; Reinstein, J.; Cryle, M. J.: Regulation of the P450 oxygenation cascade involved in glycopeptide antibiotic biosynthesis. Journal of the American Chemical Society 138 (21), pp. 6746 - 6753 (2016)

Brieke, C.; Peschke, M.; Haslinger, K.; Cryle, M. J.: Sequential in vitro cyclization by cytochrome P450 enzymes of glycopeptide antibiotic precursors bearing the X-domain from nonribosomal peptide biosynthesis. Angewandte Chemie International Edition in English 54 (52), pp. 15715 - 15719 (2015)

Toma, R. S. A.; Brieke, C.; Cryle, M. J.; Süssmuth, R. D.: Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products. Natural Product Reports 32 (8), pp. 1207 - 1235 (2015)

Haslinger, K.; Peschke, M.; Brieke, C.; Maximowitsch, E.; Cryle, M.: X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis. Nature 521 (7550), pp. 105 - 109 (2015)

Haslinger, K.; Redfield, C.; Cryle, M.: Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis. Proteins: Structure, Function, and Bioinformatics 84 (4), pp. 711 - 721 (2015)

Zhang, A.; Zhang, a. T.; Hall, a. E. A.; Hutchinson, b. S.; Cryle, M. J.; Wong, L.-L.; Zhou, W.; Bell, S. G.: The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis. Molecular BioSystems 11 (3), pp. 869 - 881 (2015)

Brieke, C.; Kratzig, V.; Haslinger, K.; Winkler, A.; Cryle, M.: Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics. Organic & Biomolecular Chemistry 13 (7), pp. 2012 - 2021 (2015)

Brieke, C.; Maier, T.; Schröter, M.; Cryle, M. J.: Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis. MedChemComm 7, pp. 132 - 140 (2015)

Haslinger, K.; Maximowitsch, E.; Brieke, C.; Koch, A.; Cryle, M.: Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis. ChemBioChem: A European Journal of Chemical Biology 15 (18), pp. 2719 - 2728 (2014)

Haslinger, K.; Brieke, C.; Uhlmann, S.; Sieverling, L.; Süssmuth, R. D.; Cryle, M.: The structure of a transient complex of a nonribosomal peptide synthetase and a cytochrome P450 monooxygenase. Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker 53 (32), pp. 8518 - 8522 (2014)

Brieke, C.; Cryle, M.: A facile Fmoc solid phase synthesis strategy to access pimerization-prone biosynthetic intermediates of glycopeptide antibiotics. Organic Letters 16 (9), pp. 2454 - 2457 (2014)

Uhlmann , S.; Süssmuth , R. D.; Cryle, M.: Cytochrome P450sky interacts directly with the nonribosomal peptide synthetase to generate three amino acid precursors in skyllamycin biosynthesis. ACS Chemical Biology 8 (11), pp. 2586 - 2596 (2013)

Erk, B.; Rolles, D.; Foucar, L.; Rudek, B.; Epp, S. W.; Cryle, M.; Bostedt, C.; Schorb, S.; Bozek, J.; Rouzee, A. et al.; Hundertmark, A.; Marchenko, T.; Simon, M.; Filsinger, F.; Christensen, L.; De, S.; Trippel, S.; Küpper, J.; Stapelfeldt, H.; Wada, S.; Ueda, K.; Swiggers, M.; Messerschmidt, M.; Schröter, C. D.; Moshammer, R.; Schlichting, I.; Ullrich, J.; Rudenko, A.: Inner-shell multiple ionization of polyatomic molecules with an intense x-ray free-electron laser studied by coincident ion momentum imaging. Journal of Physics B 46 (16), 164031, pp. 1 - 12 (2013)