Mechanisms of Force-Induced Dynamic Cell Reorganizations
We try to obtain a profound understanding of molecular and biophysical processes in force-induced cellular responses (see e.g. Biophysical Journal, 95, 3470-78, 2008). Of special interest is the temporal and spatial dynamics of the cellular acto-myosin system and focal adhesion upon application of external forces and at the migration through confined 3D-like environments.
![FRET image of Rho GTPase activity](/14103682/original-1518433942.jpg?t=eyJ3aWR0aCI6MjQ2LCJvYmpfaWQiOjE0MTAzNjgyfQ%3D%3D--a82b077c6ab9a45925a2be4e89ad15094ee65cc9)
FRET image of Rho GTPase activity
![Deformation of pancreas tumor cells at the migration through small channels](/14103687/original-1518433942.jpg?t=eyJ3aWR0aCI6MjQ2LCJvYmpfaWQiOjE0MTAzNjg3fQ%3D%3D--ff6e8342dc445207ecd4aca1732efaa08262d1dd)
Deformation of pancreas tumor cells at the migration through small channels