Mechanisms of Force-Induced Dynamic Cell Reorganizations

We try to obtain a profound understanding of molecular and biophysical processes in force-induced cellular responses (see e.g. Biophysical Journal, 95, 3470-78, 2008). Of special interest is the temporal and spatial dynamics of the cellular acto-myosin system and focal adhesion upon application of external forces and at the migration through confined 3D-like environments.

FRET image of Rho GTPase activity

Deformation of pancreas tumor cells at the migration through small channels

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