Sprengel, Rolf

Sprengel, Rolf

Research Group Leader

Main Focus

One of the most fascinating problems of modern biology concerns the molecular mechanisms which underlie the acquisition, computation and storage of information in the human brain. It has been a long-standing assumption that both the number of nerve cells and their connections in the human brain are immutable. However, over the past decades a growing body of evidence revealed that even the adult brain is able to reorganize and optimize its microstructure and internal connections. It has for instance been possible to optimize information transfer between communicating nerve cells by short intensive electrical stimuli and to measure this improvement as an increased response by the neuron, which lasts for several hours. Henceforth this test, termed long-term potentiation (LTP) in scientific textbooks, has been used as a measure for the capability of nerve cells to adapt to environmental influences, which is the equivalent of learning.
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