The institute from outside.

Max Planck Institute for Medical Research

Research at the Max Planck Institute for Medical Research has, ever since its founding in 1927 as a Kaiser Wilhelm Institute, benefited from the work of notable scientists and excellent science on the border between physiology, physics, chemistry and biology. The institute was opened on May 27, 1930, during the annual general meeting of the Kaiser Wilhelm Gesellschaft in Heidelberg.

A new direction in the 2010s

In its nearly 100-year history, the Max Planck Institute for Medical Research has undergone several fundamental reorientations, with the appointments of Joachim Spatz and Stefan Hell in 2016 and Kai Johnsson in 2017. Since then, the central focus of research has been to observe and manipulate in real time the immensely complex dynamics of interactions between macromolecules in living cells—whether healthy or diseased.

Three departments with unique expertise

The three departments at the institute contribute to these research tasks with their unique expertise in fields that complement each other very well: Stefan Hell’s department focuses on optical nanoscopy, Kai Johnsson’s department is dedicated to the design of new reporter molecules, and the department led by Joachim Spatz—who has served as the institute’s executive director since mid-2024—focuses on cellular materials science and biophysics. Additional contributions come from the research of the emeritus group led by Ilme Schlichtung as well as several other research groups.

Tools for biomedical research

The research focuses on developing new tools for biomedical research that lead to new findings, insights, and medical advances. In this way, the Institute’s research continues to uphold the vision of its founder, Ludolf von Krehl: to promote medical research through close collaboration among biologists, physicists, and chemists under one roof.

 

In the general excitement of a time when three-dimensional protein structures of whole genomes are being determined automatically, it is often forgotten that a structure in itself does not tell one how the molecule works or folds.
The primary scientific goal of the department is to develop technologies, based on physics, chemistry and materials science, for unraveling fundamental problems in cellular science, biomedical science and the engineering of life-like materials. For example, the department fundamentally investigates the organization and decision-making processes of cell collectives and organoides as well as the assembly and function of synthetic cells, designer immune cells and tissues.
The Department of Chemical Biology focusses on the visualization and manipulation of biological activities in live cells. The in vivo localization and quantification of protein activities, metabolites and other important parameters has become a central quest in biology, but the majority of cellular processes remain invisible, to date. We address this challenge by developing conceptually new tools to unravel the complexity of living cells.
The Department of Optical Nanoscopy is focused on conceiving, exploring, validating and applying optical microscopy methods with resolution far beyond the classical diffraction limit. The primary scientific direction of this new department is to push the performance of nano-optical molecular analysis in (living) cells and tissues.
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