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Journal Article (83)

1.
Journal Article
Rak, A.; Pylypenko, O.; Durek, T.; Watzke, A.; Kushnir, S.; Brunsveld, L.; Waldmann, H.; Goody, R. S.; Alexandrov, K.: Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science 302 (5645), pp. 646 - 650 (2003)
2.
Journal Article
Pylypenko, O.; Rak, A.; Reents, R.; Niculae, A.; Sidorovitch, V.; Cioaca, M.-D.; Bessolitsyna, E.; Thomä, N. H.; Waldmann, H.; Schlichting, I. et al.; Goody, R. S.; Alexandrov, K.: Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Molecular Cell 11 (2), pp. 483 - 494 (2003)
3.
Journal Article
Rak, A.; Pylypenko, O.; Niculae, A.; Goody, R. S.; Alexandrov, K.: Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1. Journal of Structural Biology 141 (1), pp. 93 - 95 (2003)
4.
Journal Article
Rak, A.; Reents, R.; Pylypenko, O.; Niculae, A.; Sidorovitch, V.; Thomä, N. H.; Waldmann, H.; Schlichting, I.; Goody, R. S.; Alexandrov, K.: Crystallization and Preliminary X-ray Diffraction Analysis of the Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase. Journal of Structural Biology 136 (2), pp. 158 - 161 (2001)
5.
Journal Article
Ostermann, N.; Lavie, A.; Padiyar, S.; Brundiers, R.; Veit, T.; Reinstein, J.; Goody, R. S.; Konrad, M.; Schlichting, I.: Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. Journal of Molecular Biology (London) 304 (1), pp. 43 - 53 (2000)
6.
Journal Article
Ostermann, N.; Schlichting, I.; Brundiers, R.; Konrad, M.; Reinstein, J.; Veit, T.; Goody, R. S.; Lavie, A.: Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate. Structure 8 (6), pp. 629 - 642 (2000)
7.
Journal Article
Brundiers, R.; Lavie, A.; Veit, T.; Reinstein, J.; Schlichting, I.; Ostermann, N.; Goody, R. S.; Konrad, M.: Modifying human thymidylate kinase to potentiate azidothymidine activation. The Journal of Biological Chemistry 274 (50), pp. 35289 - 35292 (1999)
8.
Journal Article
Goody, R.; Reinstein, J.; Scheidig, A.; Schlichting, I.: Die vierte Dimension in der molekularen Strukturforschung. Dortmunder UNI Report 1990 (Sonderheft), pp. 40 - 45 (1999)
9.
Journal Article
Gruen, M.; Becker, C.; Beste, A.; Reinstein, J.; Scheidig, A. J.; Goody, R. S.: 2′Halo-ATP and -GTP analogues: Rational phasing tools for protein crystallography. Protein Science 8 (11), pp. 2524 - 2528 (1999)
10.
Journal Article
Lavie, A.; Ostermann, N.; Brundiers, R.; Goody, R. S.; Reinstein, J.; Konrad, M.; Schlichting, I.: Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proceedings of the National Academy of Sciences of the United States of America 95 (24), pp. 14045 - 14050 (1998)
11.
Journal Article
Lavie, A.; Konrad, M.; Brundiers, R.; Goody, R. S.; Schlichting, I.; Reinstein, J.: Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation. Biochemistry 37 (11), pp. 3677 - 3686 (1998)
12.
Journal Article
Lavie, A.; Reinstein, J.; Goody, R. S.; Schlichting, I.; Konrad, M.: Reply to "Improving AZT efficacy". Nature Medicine 4, p. 132 - 132 (1998)
13.
Journal Article
Lavie, A.; Reinstein, J.; Goody, R. S.; Schlichting, I.; Konrad, M.: Improving AZT efficacy. Nature Medicine 4 (2), p. 132 - 132 (1998)
14.
Journal Article
Lavie, A.; Schlichting, I.; Vetter, I. R.; Konrad, M.; Reinstein, J.; Goody, R. S.: The bottleneck in AZT activation. Nature Medicine 3 (8), pp. 922 - 924 (1997)
15.
Journal Article
Lavie, A.; Vetter, I. R.; Konrad, M.; Goody, R. S.; Reinstein, J.; Schlichting, I.: Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nature structural biology 4 (8), pp. 601 - 604 (1997)
16.
Journal Article
Packschies, L.; Theyssen, H.; Buchberger, A.; Bukau, B.; Goody, R. S.; Reinstein, J.: GrpE accelerates nucleotide exchange of the molecular chaperone DnaK with an associative displacement mechanism. Biochemistry 36 (12), pp. 3417 - 3422 (1997)
17.
Journal Article
Schlichting, I.; Goody, R. S.: Triggering methods in crystallographic enzyme kinetics. Methods in Enzymology 277, pp. 467 - 490 (1997)
18.
Journal Article
Thrall, S. H.; Reinstein, J.; Wöhrl, B. M.; Goody, R. S.: Evaluation of human immunodeficiency virus type 1 reverse transcriptase primer tRNA binding by fluorescence spectroscopy: specificity and comparison to primer/template binding. Biochemistry 35 (14), pp. 4609 - 4618 (1996)
19.
Journal Article
Scheidig, A. J.; Franken, S. M.; Corrie, J. E. T.; Reid, G. P.; Wittinghofer, A.; Pai, E. F.; Goody, R. S.: X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and Mant dGppNHp. Journal of Molecular Biology (London) 253 (1), pp. 132 - 150 (1995)
20.
Journal Article
Rittinger, K.; Divita, G.; Goody, R. S.: Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors. Proceedings of the National Academy of Sciences of the United States of America 92 (17), pp. 8046 - 8049 (1995)
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