Publications of Julien Hiblot

Kühn, S.; Nasufovic, V.; Wilhelm, J.; Kompa, J.; de Lange, E. M.F.; Lin, Y.-H.; Egoldt, C.; Fischer, J.; Lennoi, A.; Tarnawski, M. et al.; Reinstein, J.; Vlijm, R.; Hiblot, J.; Johnsson, K.: SNAP-tag2: faster and brighter protein labeling. Nature Chemical Biology, pp. 1 - 26 (2025)

Lin, Y.-H.; Kompa, J.; Sun, D.-e.; Mao, R.; Koch, B.; Hinnah, K.; Wilhelm, J.; Franz, N.; Kühn, S.; Menche, T. et al.; Adow, A.; Breuer, P.; Hiblot, J.; Johnsson, K.: A high-affinity split-HaloTag for live-cell protein labeling. bioRxiv, pp. 1 - 52 (2025)

Wilhelm, J.; Nickel, L.; Lin, Y.-H.; Hiblot, J.; Johnsson, K.: Improving split-HaloTag through computational protein engineering. Protein Science 34 (5), e70123, pp. 1 - 10 (2025)

Hellweg, L.; Pfeifer, M.; Tarnawski, M.; Thing-Teoh, S.; Chang, L.; Bergner, A.; Kress, J.; Hiblot, J.; Wiedmer, T.; Superti-Furga, G. et al.; Reinhardt, J.; Johnsson, K.; Leippe, P.: AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells. Cell Chemical Biology 31 (8), pp. 1529 - 1541.e12 (2024)

Huppertz, M.-C.; Wilhelm, J.; Grenier, V.; Schneider, M. W.; Falt, T.; Porzberg, N.; Hausmann, D.; Hoffmann, D. C.; Hai, L.; Tarnawski, M. et al.; Pino, G.; Slanchev, K.; Kolb, I.; Acuna, C.; Fenk, L. M.; Baier, H.; Hiblot, J.; Johnsson, K.: Recording physiological history of cells with chemical labeling. Science 383 (6685), pp. 890 - 897 (2024)

Hai, L.; Hoffmann, D. C.; Wagener, R. J.; Azorin, D. D.; Hausmann, D.; Xie, R.; Huppertz, M.-C.; Hiblot, J.; Sievers, P.; Heuer, S. et al.; Ito, J.; Cebulla, G.; Kourtesakis, A.; Kaulen, L. D.; Ratliff, M.; Mandelbaum, H.; Jung, E.; Jabali, A.; Horschitz, S.; Ernst, K. J.; Reibold, D.; Warnken, U.; Venkataramani, V.; Will, R.; Suvà, M. L.; Herold-Mende, C.; Sahm, F.; Winkler, F.; Schlesner, M.; Wick, W.; Kessler, T.: A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1. Nature Communications 15 (1), 968, pp. 1 - 29 (2024)

Hellweg, L.; Edenhofer, A.; Barck, L.; Huppertz, M.-C.; Frei, M. S.; Tarnawski, M.; Bergner, A.; Koch, B.; Johnsson, K.; Hiblot, J.: A general method for the development of multicolor biosensors with large dynamic ranges. Nature Chemical Biology 19 (9), pp. 1147 - 1157 (2023)

Xue, L.; Schnacke, P.; Frei, M. S.; Koch, B.; Hiblot, J.; Wombacher, R.; Fabritz, S.; Johnsson, K.: Probing coenzyme A homeostasis with semisynthetic biosensors. Nature Chemical Biology 19 (3), pp. 346 - 355 (2023)

Glogger, M.; Wang, D.; Kompa, J.; Balakrishnan, A.; Hiblot, J.; Barth, H.-D.; Johnsson, K.; Heilemann, M.: Synergizing exchangeable fluorophore labels for multitarget STED microscopy. ACS Nano 16 (11), pp. 17991 - 17997 (2022)

Frei, M. S.; Koch, B.; Hiblot, J.; Johnsson, K.: Live-cell fluorescence lifetime multiplexing using synthetic fluorescent probes. ACS Chemical Biology 17 (6), pp. 1321 - 1327 (2022)

Mertes, N.; Busch, M.; Huppertz, M.-C.; Hacker, C. N.; Gürth, C.-M.; Kühn, S.; Hiblot, J.; Koch, B.; Johnsson, K.: Fluorescent and bioluminescent calcium indicators with tuneable colors and affinities. Journal of the American Chemical Society 144 (15), pp. 6928 - 6935 (2022)

Kompa, J.; Bruins, J.; Glogger, M.; Wilhelm, J.; Frei, M. S.; Tarnawski, M.; D´Este, E.; Heilemann, M.; Hiblot, J.; Johnsson, K.: Exchangeable HaloTag ligands for super-resolution fluorescence microscopy. Journal of the American Chemical Society 145 (5), pp. 3075 - 3083 (2022)

Frei, M. S.; Tarnawski, M.; Roberti, M. J.; Koch, B.; Hiblot, J.; Johnsson, K.: Engineered HaloTag variants for fluorescence lifetime multiplexing. Nature Methods 19, pp. 65 - 70 (2022)

Wilhelm, J.; Kühn, S.; Tarnawski, M.; Gotthard, G.; Tünnermann, J.; Tänzer, T.; Karpenko, J.; Mertes, N.; Xue, L.; Uhrig, U. et al.; Reinstein, J.; Hiblot, J.; Johnsson, K.: Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag, and CLIP-tag. Biochemistry 60 (33), pp. 2560 - 2575 (2021)

Wang, L.; Hiblot, J.; Popp, C.; Xue, L.; Johnsson, K.: Environmentally sensitive color‐shifting fluorophores for bioimaging. Angewandte Chemie International Edition 59 (49), pp. 21880 - 21884 (2020)

Farrants, H.; Tarnawski, M.; Müller, T. G.; Otsuka, S.; Hiblot, J.; Koch, B.; Kueblbeck, M.; Kräusslich, H.-G.; Ellenberg, J.; Johnsson, K.: Chemogenetic control of nanobodies. Nature methods 17, pp. 279 - 282 (2020)

Yu, Q.; Xue, L.; Hiblot, J.; Griss , R.; Fabritz, S.; Roux, C.; Binz, P.-A.; Haas, D.; Okun, J. G.; Johnsson, K.: Semisynthetic sensor proteins enable metabolic assays at the point of care. Science 361 (6407), pp. 1122 - 1126 (2018)

Hiblot, J.; Yu, Q.; Sabbadini , M. D.B.; Reymond, L.; Xue, L.; Schena , A.; Sallin , O.; Hill , N.; Griss , R.; Johnsson, K.: Luciferases with tunable emission wavelengths. Angewandte Chemie, International Edition in English 56 (46), pp. 14556 - 14560 (2017)

Farrants , H.; Hiblot, J.; Griss , R.; Johnsson, K.: Rational design and applications of semisynthetic modular biosensors: SNIFITs and LUCIDs. Methods in Molecular Biology 1596 , pp. 101 - 117 (2017)