Theranostic nanogels: We are interested in the development of hydrophilic soft nanogels as carriers for diagnostic and therapeutic radioisotopes(in collaboration with Nuclear Medicine Department, Uniklink Aachen). Exploiting both, the passive enhanced permeation and retention effect (EPR) and the active peptide-receptor based delivery, we aim to improve the pharmacokinetics for endogeneous radiotherapy.
Endogenous radiation therapy involves the intravenous application of radiolabeled nanocarriers which can be imaged via nuclear medicine imaging tools such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). By changing the type of radionuclide the nanocarrier can be employed as a diagnostic or a therapeutic tool. The image shows µ-PET images of healthy wistar rat (60min dynamic measurement) after injection with [68Ga]Ga- nanogels
Smriti Singh
Endogenous radiation therapy involves the intravenous application of radiolabeled nanocarriers which can be imaged via nuclear medicine imaging tools such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). By changing the type of radionuclide the nanocarrier can be employed as a diagnostic or a therapeutic tool. The image shows µ-PET images of healthy wistar rat (60min dynamic measurement) after injection with [68Ga]Ga- nanogels
Smriti Singh
1. Singh, S.* et al. Protease Responsive Nanogels for Transcytosis across the Blood−Brain Barrier and Intracellular Delivery of Radiopharmaceuticals to Brain Tumor Cells. Advanced healthcare materials10, 2100812, 2021.
2. N. Drude, O. H. Winz, F. M. Mottaghy, M. Roller, H. Königs, M. Möller, S. Singh* and A. Morgenroth*, Small, 14, e1704093, 2018.
![Endogenous radiation therapy involves the intravenous application of radiolabeled nanocarriers which can be imaged via nuclear medicine imaging tools such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). By changing the type of radionuclide the nanocarrier can be employed as a diagnostic or a therapeutic tool. The image shows µ-PET images of healthy wistar rat (60min dynamic measurement) after injection with [68Ga]Ga- nanogels](/14565493/original-1646050730.webp?t=eyJ3aWR0aCI6MTY5NiwiZmlsZV9leHRlbnNpb24iOiJ3ZWJwIiwib2JqX2lkIjoxNDU2NTQ5M30%3D--12f69bc0468bd3a9612597659cd0fa9d2eeb5839 "Endogenous radiation therapy involves the intravenous application of radiolabeled nanocarriers which can be imaged via nuclear medicine imaging tools such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). By changing the type of radionuclide the nanocarrier can be employed as a diagnostic or a therapeutic tool. The image shows µ-PET images of healthy wistar rat (60min dynamic measurement) after injection with [68Ga]Ga- nanogels")
![Endogenous radiation therapy involves the intravenous application of radiolabeled nanocarriers which can be imaged via nuclear medicine imaging tools such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). By changing the type of radionuclide the nanocarrier can be employed as a diagnostic or a therapeutic tool. The image shows µ-PET images of healthy wistar rat (60min dynamic measurement) after injection with [68Ga]Ga- nanogels](/14565493/original-1646050730.jpg?t=eyJ3aWR0aCI6MjQ2LCJvYmpfaWQiOjE0NTY1NDkzfQ%3D%3D--04faac368253f22c935b8121c59f2d01ccdee86f)