Publications

Sarott, R. C.; Gourisankar, S.; Karim, B.; Nettles, S.; Yang, H.; Dwyer, B. G.; Simanauskaite, J. M.; Tse, J.; Abuzaid, H.; Krokhotin, A. et al.; Zhang, T.; Hinshaw, S. M. ..; Green, M. R.; Crabtree, G. R.; Gray, N. S.: Relocalizing transcriptional kinases to activate apoptosis. Science 386 (6717), pp. 1 - 9 (2024)

Razumkov, H.; Jiang, Z.; Baek, K.; You, I.; Geng, Q.; Donovan, K. A.; Tang, M. T.; Metivier, R. J.; Mageed, N.; Seo, P. et al.; Li, Z.; Byun, W. S.; Hinshaw, S. M.; Sarott, R. C.; Fischer, E. S.; Gray, N. S.: Discovery of CRBN-dependent WEE1 molecular glue degraders from a multicomponent combinatorial library. bioRxiv, 2024.05.04.592550 (2024)

Kosar, M.; Sarott, R. C.; Sykes, D. A.; Viray, A. E. G.; Vitale, R. M.; Tomašević, N.; Li, X.; Ganzoni, R. L. Z.; Kicin, B.; Reichert, L. et al.; Patej, K. J.; Gómez-Bouzó, U.; Guba, W.; McCormick, P. J.; Hua, T.; Gruber, C. W.; Veprintsev, D. B.; Frank, J. A.; Grether, U.; Carreira, E. M.: Flipping the GPCR switch: structure-based development of selective cannabinoid receptor 2 inverse agonists. ACS Central Science 10 (5), pp. 956 - 968 (2024)

Sarott, R. C.; You, I.; Li, Y.-D.; Toenjes, S. T.; Donovan, K. A.; Seo, P.; Ordonez, M.; Byun, W. S.; Hassan, M. M.; Wachter, F. et al.; Chouchani, E. T.; Słabicki, M.; Fischer, E. S.; Ebert, B. L.; Hinshaw, S. M.; Gray, N. S.: Chemical specification of E3 ubiquitin ligase engagement by cysteine-reactive chemistry. Journal of the American Chemical Society 145 (40), pp. 21937 - 21944 (2023)

Freis, M.; Balkenhohl, M.; Fischer, D. M.; Georgiev, T.; Sarott, R. C.; Carreira, E. M.: Cobalt-catalyzed aerobic aminocyclization of unsaturated amides for the synthesis of functionalized γ- and δ-lactams. Organic Letters 25 (34), pp. 6380 - 6384 (2023)

Kosar, M.; Sykes, D. A.; Viray, A. E. G.; Vitale, R. M.; Sarott, R. C.; Ganzoni, R. L.; Onion, D.; Tobias, J. M.; Leippe, P.; Ullmer, C. et al.; Zirwes, E. A.; Guba, W.; Grether, U.; Frank, J. A.; Veprintsev, D. B.; Carreira, E. M.: Platform reagents enable synthesis of ligand-directed covalent probes: study of cannabinoid receptor 2 in live cells. Journal of the American Chemical Society 145 (28), pp. 15094 - 15108 (2023)

de Esteban, S. R. M.; Benito-Cuesta, I.; Terradillos, I.; Martínez-Relimpio, A. M.; Arnanz, M. A.; Ruiz-Pérez, G.; Korn, C.; Raposo, C.; Sarott, R. C.; Westphal, M. V. et al.; Elezgarai, I.; Carreira, E. M.; Hillard, C. J.; Grether, U.; Grandes, P.; Grande, M. T.; Romero, J.: Cannabinoid CB2 receptors modulate microglia function and amyloid dynamics in a mouse model of alzheimer's disease. Frontiers in Pharmacology 13, 841766, pp. 1 - 12 (2022)

Gazzi, T.; Brennecke, B.; Atz, K.; Korn, C.; Sykes, D.; Forn-Cuni, G.; Pfaff, P.; Sarott, R. C.; Westphal, M. V.; Mostinski, Y. et al.; Mach, L.; Wasinska-Kalwa, M.; Weise, M.; Hoare, B. L.; Miljuš, T.; Mexi, M.; Roth, N.; Koers, E. J.; Guba, W.; Alker, A.; Rufer, A. C.; Kusznir, E. A.; Huber, S.; Raposo, C.; Zirwes, E. A.; Osterwald, A.; Pavlovic, A.; Moes, S.; Beck, J.; Nettekoven, M.; Benito-Cuesta, I.; Grande, T.; Drawnel, F.; Widmer, G.; Holzer, D.; van der Wel, T.; Mandhair, H.; Honer, M.; Fingerle, J.; Scheffel, J.; Broichhagen, J.; Gawrisch, K.; Romero, J.; Hillard, C. J.; Varga, Z. V.; van der Stelt, M.; Pacher, P.; Gertsch, J.; Ullmer, C.; McCormick, P. J.; Oddi, S.; Spaink, H. P.; Maccarrone, M.; Veprintsev, D. B.; Carreira, E. M.; Grether, U.; Nazaré, M.: Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science 13 (19), pp. 5539 - 5545 (2022)

Müller, M.; Gräbnitz, F.; Barandun, N.; Shen, Y.; Wendt, F.; Steiner, S. N.; Severin, Y.; Vetterli, S. U.; Mondal, M.; Prudent, J. R. et al.; Hofmann, R.; van Oostrum, M.; Sarott, R. C.; Nesvizhskii, A. I.; Carreira, E. M.; Bode, J. W.; Snijder, B.; Robinson, J. A.; Loessner, M. J.; Oxenius, A.; Wollscheid, B.: Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks. Nature Communications 12, 7036 , pp. 1 - 17 (2021)

Sarott, R. C.; Viray, A. E. G.; Pfaff, P.; Sadybekov, A.; Rajic, G.; Katritch, V.; Carreira, E. M.; Frank, J. A.: Optical control of cannabinoid receptor 2-mediated Ca2+ release enabled by synthesis of photoswitchable probes. Journal of the American Chemical Society 143 (2), pp. 736 - 743 (2021)

Sarott, R. C.; Westphal, M. V.; Pfaff, P.; Korn, C.; Sykes, D. A.; Gazzi, T.; Brennecke, B.; Atz, K.; Weise, M.; Mostinski, Y. et al.; Hompluem, P.; Koers, E.; Miljuš, T.; Roth, N. J.; Asmelash, H.; Vong, M. C.; Piovesan, J.; Guba, W.; Rufer, A. C.; Kusznir, E. A.; Huber, S.; Raposo, C.; Zirwes, E. A.; Osterwald, A.; Pavlovic, A.; Moes, S.; Beck, J.; Benito-Cuesta, I.; Grande, T.; de Esteban, S. R. M. N.; Yeliseev, A.; Drawnel, F.; Widmer, G.; Holzer, D.; van der Wel, T.; Mandhair, H.; Yuan, C.-Y.; Drobyski, W. R.; Saroz, Y.; Grimsey, N.; Honer, M.; Fingerle, J.; Gawrisch, K.; Romero, J.; Hillard, C. J.; Varga, Z. V.; van der Stelt, M.; Pacher, P.; Gertsch, J.; McCormick, P. J.; Ullmer, C.; Oddi, S.; Maccarrone, M.; Veprintsev, D. B.; Nazaré, M.; Grether, U.; Carreira, E. M.: Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells. Journal of the American Chemical Society 142 (40), pp. 16953 - 16964 (2020)

Westphal, M. V.; Sarott, R. C.; Zirwes, E. A.; Osterwald, A.; Guba, W.; Ullmer, C.; Grether, U.; Carreira, E. M.: Highly selective, amine-derived cannabinoid receptor 2 probes. Chemistry – A European Journal 26 (6), pp. 1380 - 1387 (2020)

Westphal, M. V.; Schafroth, M. A.; Sarott, R. C.; Imhof, M. A.; Bold, C. P.; Leippe, P.; Dhopeshwarkar, A.; Grandner, J. M.; Katritch, V.; Mackie, O. et al.; Trauner, D.; Carreira, E. M.; Frank, J. A.: Synthesis of photoswitchable Δ9-tetrahydrocannabinol derivatives enables optical control of cannabinoid receptor 1 signaling. Journal of the American Chemical Society 139 (50), pp. 18206 - 18212 (2017)

Santschi, N.; Sarott, R. C.; Otth, E.; Kissner, R.; Togni, A.: Synthesis, characterization and initial evaluation of 5-nitro-1-(trifluoromethyl)-3H-1λ3,2-benziodaoxol-3-one. Beilstein Journal of Organic Chemistry 10, pp. 1 - 6 (2014)

Kosar, M.; Carreira, E. M.; Grether, U.; Sarott, R. C.; Guba, W.; Ganzoni, R. L. Z.: Covalent fluorescent probes for cannabinoid receptor 2. WO/2024/042146 (2024)

Crabtree, G. R.; Gray, N.; Gourisankar, S.; Krokhotin, A.; Ji, W.; Sarott, R.; Zhang, T.; Karim, B.; Chang, C.-Y.; Kim, S. H.: Compositions, systems, and methods for modulationg a target gene. WO2023/215311 (2023)

Carreira, E. M.; Sarott, R.; Pfaff, P.; Hurni, K.; Roth, R.; Eichenberger, S.; Stäubli, J.: Conversion of THC, CBD and their derivatives to Cannabinol. US20230002341 (2023)