Publications of Clara Brieke

Heimes, M.; Kolmar, L.; Brieke, C.: Efficient cosubstrate enzyme pairs for sequence-specific methyltransferase-directed photolabile caging of DNA. Chemical Communications 54 (90), pp. 12718 - 12721 (2018)

Brieke, C.; Tarnawski, M.; Greule, A.; Cryle, M. J.: Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach. Journal of Inorganic Biochemistry 185, pp. 43 - 51 (2018)

Rocker, A.; Peschke, M.; Kittilä, T.; Sakson, R.; Brieke, C.; Meinhart, A.: The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis. Nature Communications 9, 1686, pp. 1 - 11 (2018)

Peschke, M.; Brieke, C.; Goode, R. J. A.; Schittenhelm, R. B.; Cryle, M.: Chlorinated glycopeptide antibiotic peptide precursors improve cytochrome P450-catalyzed cyclization cascade efficiency. Biochemistry 56 (9), pp. 1239 - 1247 (2017)

Ulrich, V.; Brieke, C.; Cryle, M.: Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934. Beilstein Journal of Organic Chemistry 12, pp. 2849 - 2864 (2016)

Brieke, C.; Yim, G.; Peschke, M.; Wright, G. D.; Cryle, M. J.: Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates. Chemical Communications 52 (94), pp. 13679 - 13682 (2016)

Ulrich, V.; Peschke, M.; Brieke, C.; Cryle, M.: More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH. Molecular BioSystems 12 (10), pp. 2992 - 3004 (2016)

Peschke, M.; Brieke, C.; Cryle, M. J.: F-O-G ring formation in glycopeptide antibiotic biosynthesis is catalysed by OxyE. Scientific Reports 6, 35584, pp. 1 - 9 (2016)

Schuebel, F.; Rocker, A.; Edelmann, D.; Schessner, J.; Brieke, C.; Meinhart, A.: 3'-Nadp and 3'-Naadp - two metabolites formed by the bacterial type III effector AvrRxo1. The Journal of Biological Chemistry 291 (44), pp. 22868 - 22880 (2016)

Peschke, M.; Haslinger, K.; Brieke, C.; Reinstein, J.; Cryle, M. J.: Regulation of the P450 oxygenation cascade involved in glycopeptide antibiotic biosynthesis. Journal of the American Chemical Society 138 (21), pp. 6746 - 6753 (2016)

Brieke, C.; Peschke, M.; Haslinger, K.; Cryle, M. J.: Sequential in vitro cyclization by cytochrome P450 enzymes of glycopeptide antibiotic precursors bearing the X-domain from nonribosomal peptide biosynthesis. Angewandte Chemie International Edition in English 54 (52), pp. 15715 - 15719 (2015)

Toma, R. S. A.; Brieke, C.; Cryle, M. J.; Süssmuth, R. D.: Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products. Natural Product Reports 32 (8), pp. 1207 - 1235 (2015)

Haslinger, K.; Peschke, M.; Brieke, C.; Maximowitsch, E.; Cryle, M.: X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis. Nature 521 (7550), pp. 105 - 109 (2015)

Brieke, C.; Kratzig, V.; Haslinger, K.; Winkler, A.; Cryle, M.: Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics. Organic & Biomolecular Chemistry 13 (7), pp. 2012 - 2021 (2015)

Brieke, C.; Maier, T.; Schröter, M.; Cryle, M. J.: Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis. MedChemComm 7, pp. 132 - 140 (2015)

Haslinger, K.; Maximowitsch, E.; Brieke, C.; Koch, A.; Cryle, M.: Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis. ChemBioChem: A European Journal of Chemical Biology 15 (18), pp. 2719 - 2728 (2014)

Haslinger, K.; Brieke, C.; Uhlmann, S.; Sieverling, L.; Süssmuth, R. D.; Cryle, M.: The structure of a transient complex of a nonribosomal peptide synthetase and a cytochrome P450 monooxygenase. Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker 53 (32), pp. 8518 - 8522 (2014)

Brieke, C.; Cryle, M.: A facile Fmoc solid phase synthesis strategy to access pimerization-prone biosynthetic intermediates of glycopeptide antibiotics. Organic Letters 16 (9), pp. 2454 - 2457 (2014)

Brieke, C.; Kratzig, V.; Peschke, M.; Cryle, M. J.: Facile synthetic access to glycopeptide antibiotic precursor peptides for the investigation of cytochrome P450 action in glycopeptide antibiotic biosynthesis. In: Nonribosomal Peptide and Polyketide Biosynthesis, Vol. 1401, pp. 85 - 102. Springer, New York (2016)

Cryle, M.; Brieke, C.; Haslinger, K.: Oxidative transformations of amino acids and peptides catalysed by cytochromes P450. In: Amino Acids, Peptides and Proteins, Vol. 38, pp. 1 - 36 (Eds. Farkas, E.; Ryadnov , M.). Royal Society of Chemistry, Oxfordshire, UK (2013)