Publications of Miyoko Higuchi

Liddicoat, B. J.; Piskol, R.; Chalk, A. M.; Ramaswami, G.; Higuchi, M.; Hartner, J. C.; Li, J. B.; Seeburg, P. H.; Walkley, C. R.: RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science 349 (6252), pp. 1115 - 1120 (2015)

Huang, H.; Tan, B. Z.; Shen, Y.; Tao, J.; Jiang, F.; Sung, Y. Y.; Ng, C. K.; Raida, M.; Köhr, G.; Higuchi, M. et al.; Fatemi−Shariatpanahi, H.; Harden, B.; Yue, D. T.; Soong, T. W.: RNA editing of the IQ domain in cav1.3 channels modulates their ca2+-dependent inactivation. Neuron 73 (2), pp. 304 - 316 (2012)

Horsch, M.; Seeburg, P. H.; Adler, T.; Aguilar−Pimentel, J. A.; Becker, L.; Calzada−Wack, J.; Garrett, L.; Götz, A.; Hans, W.; Higuchi, M. et al.; Hölter, S. M.; Naton, B.; Prehn, C.; Puk, O.; Rácz, I.; Rathkolb, B.; Rozman, J.; Schrewe, A.; Adamski, J.; Busch, D. H.; Esposito, I.; Graw, J.; Ivandic, B.; Klingenspor, M.; Klopstock, T.; Mempel, M.; Ollert, M.; Schulz, H.; Wolf, E.; Wurst, W.; Zimmer, A.; Gailus−Durner, V.; Fuchs, H.; Hrabe de Angelis, M.; Beckers, J.: Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. The Journal of Biological Chemistry 286 (21), pp. 18614 - 18622 (2011)

Yang, W.; Chendrimada, T. P.; Wang, Q.; Higuchi, M.; Seeburg, P. H.; Shiekhattar, R.; Nishikura, K.: Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nature Structural and Molecular Biology 13 (1), pp. 13 - 21 (2006)

Hartner, J. C.; Schmittwolf, C.; Kispert, A.; Müller, A.; Higuchi, M.; Seeburg, P. H.: Liver disintegration in the mouse embryo by deficiency in RNA editing enzyme ADAR1. The Journal of Biological Chemistry 279 (6), pp. 4894 - 4902 (2004)

Seeburg, P. H.; Single, F. N.; Kuner, T.; Higuchi, M.; Sprengel, R.: Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse. Brain Research 907 (1), pp. 233 - 243 (2001)

Higuchi, M.; Maas, S.; Single, F. N.; Hartner, J. C.; Rozov, A.; Burnashev, N.; Feldmeyer, D.; Sprengel, R.; Seeburg, P. H.: Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 406 (6791), pp. 78 - 81 (2000)

Jerecic, J.; Single, F. N.; Krüth, U.; Krestel, H. E.; Kolhekar, R.; Storck, T.; Kask, K.; Higuchi, M.; Sprengel, R.; Seeburg, P. H.: Studies on conditional gene expression in the brain. Annals of the New York Academy of Sciences 868, pp. 27 - 37 (1999)

Seeburg, P. H.; Higuchi, M.; Sprengel, R.: RNA editing of brain glutamate receptor channels: mechanism and physiology. Brain Research Reviews 26 (2-3), pp. 217 - 229 (1998)

Seeburg, P. H.; Brusa, R.; Higuchi, M.; Sprengel, R.: Glutamate receptor channels, RNA editing, and epilepsy. Ernst Schering Research Foundation workshop 23 (1), pp. 1 - 17 (1998)

Mittaz, L.; Scott, H. S.; Rossier, C.; Seeburg, P. H.; Higuchi, M.; Antonarakis, S. E.: Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3. Genomics 41 (2), pp. 210 - 217 (1997)

Melcher, T.; Maas, S.; Herb, A.; Sprengel, R.; Higuchi, M.; Seeburg, P. H.: RED2, a brain specific member of the RNA specific adenosine deaminase family. The Journal of Biological Chemistry 271 (50), pp. 31795 - 31798 (1996)

Maas, S.; Melcher, T.; Herb, A.; Seeburg, P. H.; Keller, W.; Krause, S.; Higuchi, M.; O'Connell , M. A.: Structural requirements for RNA editing in glutamate receptor pre-mRNAs by recombinant double-stranded RNA adenosine deaminase. The Journal of Biological Chemistry 271 (21), pp. 12221 - 12226 (1996)

Herb, A.; Higuchi, M.; Sprengel, R.; Seeburg, P. H.: Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proceedings of the National Academy of Sciences of the United States of America 93 (5), pp. 1875 - 1880 (1996)

Melcher, T.; Maas, S.; Herb, A.; Sprengel, R.; Seeburg, P. H.; Higuchi, M.: A mammalian RNA editing enzyme. Nature 379, pp. 460 - 464 (1996)

Melcher, T.; Maas, S.; Higuchi, M.; Keller, W.; Seeburg, P. H.; Major, G.; Larkman, A. U.; Jonas, P.; Sakmann, B.; Jack, J. J. B.: Editing of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR-B Pre-mRNA in Vitro Reveals Site-selective Adenosine to Inosine Conversion. The Journal of Biological Chemistry 270 (15), pp. 8566 - 8570 (1995)

Lomeli, H.; Mosbacher, J.; Melcher, T.; Höger, T.; Geiger, J. R. P.; Kuner, T.; Monyer, H.; Higuchi, M.; Bach, A. W. J.; Seeburg, P. H.: Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science 266 (5191), pp. 1709 - 1713 (1994)

Higuchi, M.; Single, F. N.; Köhler, M.; Sommer, B.; Sprengel, R.; Seeburg, P. H.: RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency. Cell 75 (7), pp. 1361 - 1370 (1993)

Monyer, H.; Sprengel, R.; Schöpfer, R.; Herb, A.; Higuchi, M.; Lomeli, H.; Burnashev, N.; Sakmann, B.; Seeburg, P. H.: Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256 (5060), pp. 1217 - 1221 (1992)

Sprengel, R.; Higuchi, M.; Monyer, H.; Seeburg, P. H.: Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy. In: Jasper's basic mechanisms of the epilepsies: Advances in neurology 3rd. Edition, Vol. 79, pp. 525 - 534 (Eds. Delgado-Escueta, A. V.; Jasper, H. H.). Lippincott Williams & Wilkins, Philadelphia [u.a.] (1999)